2015•Zenodo (CERN European Organization for Nuclear Research)Open access
Synthesis and anthelmintic activity studies of 1-substituted benzimidazole derivatives
M. Himaja, B. Sirisha, Moonjit Das, D. Munirajsekhar
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Abstract
Pharmaceutical Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India E-mail : drmhimaja@gmail.com Faculty of Science and Humanities, Vel Tech Dr. RR & Dr. SR Technical University, Avadi, Chennai-600 062, India A new series of benzimidazoles were prepared by treating o-phenylenediamine and formic acid under reflux conditions. Further 1-substituted derivatives of benzimidazoles were synthesized by reaction with chloroacetic acid followed by condensation with amino containing compounds. The structural elucidation of the compounds was performed by FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds were subjected to anthelmintic activity studies against Eudrilus species. The title compounds exhibited moderate to good anthelmintic activity.