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Abstract
A study of patients taking ritonavir and methadone indicates that ritonavir lowers bioavailability of methadone by 30 to 40 percent. Addjusting the methadone dosage may be necessary when ritonavir is used. While the protease inhibitor nelfinavir may have the same effect, saquinavir and indinavir are not predicted to cause this problem.
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A study of patients taking ritonavir and methadone indicates that ritonavir lowers bioavailability of methadone by 30 to 40 percent. Addjusting the methadone dosage may be necessary when ritonavir is used. While the protease inhibitor nelfinavir may have the same effect, saquinavir and indinavir are not predicted to cause this problem.
Key concepts: Saquinavir, Nelfinavir, Ritonavir, Indinavir, Methadone, Pharmacology, Protease inhibitor (pharmacology), Medicine