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7-HYDROXYLATION OF DEHYDROEPIANDROSTERONE IN HUMAN FOETAL LIVER, ADRENALS AND CHORION IN VITRO

J Šulcová, A Capková, J. Ev. Jirásek, Luboslav Stárka

Open publisher page 35 citations

Abstract

ABSTRACT Tissues from 30 human foetuses aged 5 to 22 weeks were used for the investigation of Δ5-steroid 7-hydroxylase activity. Homogenised liver, adrenals and chorion were incubated with dehydroepiandrosterone or 4-14C-dehydroepiandrosterone; 7α- and 7β-hydroxydehydroepiandrosterone were identified as incubation products. Conversion of dehydroepiandrosterone to 7-hydroxylated compounds per 100 mg tissue was found to be highest in the liver and lowest in the chorion. No definite dependence of 7-hydroxylase activity on the developmental stage of the foetus was observed.

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What this paper is about

ABSTRACT Tissues from 30 human foetuses aged 5 to 22 weeks were used for the investigation of Δ5-steroid 7-hydroxylase activity. Homogenised liver, adrenals and chorion were incubated with dehydroepiandrosterone or 4-14C-dehydroepiandrosterone; 7α- and 7β-hydroxydehydroepiandrosterone were identified as incubation products. Conversion of dehydroepiandrosterone to 7-hydroxylated compounds per 100 mg tissue was found to be highest in the liver and lowest in the chorion. No definite dependence of 7-hydroxylase activity on the developmental stage of the foetus was observed.

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Available abstract

ABSTRACT Tissues from 30 human foetuses aged 5 to 22 weeks were used for the investigation of Δ5-steroid 7-hydroxylase activity. Homogenised liver, adrenals and chorion were incubated with dehydroepiandrosterone or 4-14C-dehydroepiandrosterone; 7α- and 7β-hydroxydehydroepiandrosterone were identified as incubation products. Conversion of dehydroepiandrosterone to 7-hydroxylated compounds per 100 mg tissue was found to be highest in the liver and lowest in the chorion. No definite dependence of 7-hydroxylase activity on the developmental stage of the foetus was observed.

Key concepts: Androsterone, Dehydroepiandrosterone, Endocrinology, Internal medicine, Incubation, Fetus, Hydroxylation, Chemistry

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7-HYDROXYLATION OF DEHYDROEPIANDROSTERONE IN HUMAN FOETAL LIVER, ADRENALS AND CHORION IN VITRO — Research Paper | ScholarLens