Drug allergy

Drug allergy is defined as the adverse drug reaction provoked by immunological mechanisms or roughly “type B” reaction,the mechanism of which cannot be explained by its own pharmacological mechanism. Drug allergy rarely happens in clinicalpractice, however, is usually dose-independent, unpredictable, and relatively severe in clinical manifestations. To find the safealternatives and to prevent further reactions, the causative agents should be investigated. Complete history taking of exposeddrugs and drug provocation tests are the mainstay in the diagnosis of the culprit drugs. The information of culprit drugs shouldbe opened and shared among healthcare providers for the further drug safety, called as pharmacovigilance.