2022•International Journal of Molecular SciencesOpen access

OSM/OSMR and Interleukin 6 Family Cytokines in Physiological and Pathological Condition

Francesca Lantieri, Tiziana Bachetti

Abstract

Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and can bind two different receptors, Leukemia inhibitory factor receptor (LIFR) and Oncostatin M receptor (OSMR), through a complex containing the common glycoprotein 130 (gp130) subunit [...].

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Key concepts: Oncostatin M, Glycoprotein 130, Leukemia inhibitory factor receptor, Leukemia inhibitory factor, Receptor, Interleukin 10 receptor, alpha subunit, Interleukin 6, Biology