2022•Infection and ImmunityOpen access

The Transcriptional Regulator SpxA1 Influences the Morphology and Virulence of Listeria monocytogenes

Monica R. Cesinger, Oluwasegun I. Daramola, Lucy M. Kwiatkowski, Michelle L. Reniere

Abstract

Listeria monocytogenes is a Gram-positive facultative anaerobe and an excellent model pathogen for investigating regulatory changes that occur during infection of a mammalian host. SpxA1 is a widely conserved transcriptional regulator that induces expression of peroxide-detoxifying genes in L. monocytogenes and is thus required for aerobic growth.

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Key concepts: Biology, Listeria monocytogenes, Virulence, Regulator, Microbiology, Listeria, Virology, Bacteria