Uterine Smooth Muscle Tumors: A Review

Uterine smooth muscle tumors heterogeneous tumors include at least six histologically defined tumor types. Smooth muscle tumors are divided into two categories: benign leiomyomas and malignant leiomyosarcomas. Uterine smooth muscle tumors have also morphological variants that are difficult to interpret and identify as benign or malignant called "smooth muscle tumors of uncertain malignant potential". Immunohistochemistry for progesterone receptor and p53 is useful as a supplement to morphological evaluation of uterine smooth muscle tumors that are causing problems. It might be hard to differentiate between endometrial stromal sarcomas and uterine smooth muscle tumors.