A Meta-analysis of the Hospital Stay and Hypoxic Effect of Neuromuscular Blocking Agent Antagonists, Sugammadex and Neostigmine

Background: Considering that the postoperative residual curarization rate may vary between 5% and 85% depending on the anesthetic applications, according to current scientific publications, many patients recovering from anesthesia are at serious risk.Our aim in this meta-analysis study is to reveal the comparative effects of sugammadex and neostigmine drugs used for decurarization on hospitalization and hypoxia. Materials and Methods:The terms "sugammadex", "neostigmine", "anesthesia", "neuromuscular blockade", "neuromuscular blocking agents" "sugammadex and neostigmine" were searched in the electronic databases of PubMed, DynaMed, Google Scholar."Clinical research" as search filters, the terms "controlled clinical trial" and "randomized controlled trial" were used, and the data were analyzed by a fixed effect (I 2 <25%) or random effects (I 2 >25%) model according to the presence of heterogeneity.Results: After the database search, a total of 1902 articles were found.After excluding repetitive articles, 1033 articles were reviewed.Whether they were related to the subject or not was determined by reviewing the title and summary sections.The full text of 50 articles that might be relevant is reviewed.As a result, 13 articles were included in the meta-analysis.As a result of the analysis, it was observed that the studies were heterogeneous (I 2 =97.9%;I 2 =90.5%).Analysis according to the random-effects model.It was found that the duration of hospital stay and SPO 2 levels after surgery were not different in patients given sugammadex and neostigmine [standardised mean difference (SMD)=-0.0042;95% confidence interval (CI) (-0.0459-0.0375),p=0.8438;SMD=-0.0017;95% CI (-0.01076-0.1111);p=0.9753]. Conclusion:The results of this meta-analysis show that sugammadex is no more effective in recovery from neuromuscular blockade than neostigmine in terms of hospital stay and SPO 2 .