2022Mathematical Biosciences & EngineeringOpen access

Global stability of an age-structured infection model in vivo with two compartments and two routes

Tsuyoshi Kajiwara, Toru Sasaki, Yoji Otani

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Abstract

In this paper, for an infection age model with two routes, virus-to-cell and cell-to-cell, and with two compartments, we show that the basic reproduction ratio $ R_0 $ gives the threshold of the stability. If $ R_0 > 1 $, the interior equilibrium is unique and globally stable, and if $ R_0 \le 1 $, the disease free equilibrium is globally stable. Some stability results are obtained in previous research, but, for example, a complete proof of the global stability of the disease equilibrium was not shown. We give the proof for all the cases, and show that we can use a type reproduction number for this model.

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What this paper is about

In this paper, for an infection age model with two routes, virus-to-cell and cell-to-cell, and with two compartments, we show that the basic reproduction ratio $ R_0 $ gives the threshold of the stability. If $ R_0 > 1 $, the interior equilibrium is unique and globally stable, and if $ R_0 \le 1 $, the disease free equilibrium is globally stable. Some stability results are obtained in previous research, but, for example, a complete proof of the global stability of the disease equilibrium was not shown. We give the proof for all the cases, and show that we can use a type reproduction number for this model.

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Available abstract

In this paper, for an infection age model with two routes, virus-to-cell and cell-to-cell, and with two compartments, we show that the basic reproduction ratio $ R_0 $ gives the threshold of the stability. If $ R_0 > 1 $, the interior equilibrium is unique and globally stable, and if $ R_0 \le 1 $, the disease free equilibrium is globally stable. Some stability results are obtained in previous research, but, for example, a complete proof of the global stability of the disease equilibrium was not shown. We give the proof for all the cases, and show that we can use a type reproduction number for this model.

Key concepts: Basic reproduction number, Stability (learning theory), Reproduction, Stability theory, In vivo, Mathematical economics, Mathematics, Applied mathematics

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