Five Factors to Consider before Treatment of a Hyaluronic Acid Filler-Induced Vascular Complications

Soft tissue fillers are common aesthetic procedures for facial rejuvenation.[ 1 ] Among the fillers in the market, hyaluronic acid filler has been the most popular because it is degraded by hyaluronidase. The most serious complications of filler injections are vascular complications, such as skin necrosis and ocular sequelae. Various treatment modalities, including hyaluronidase injection, have been proposed. Hyaluronidase, which normally exists in human tissues, dissolves hyaluronic acid. It degrades the β 1,4 chain of the disaccharide hyaluronic acid. The hyaluronic acid filler can be degraded by hyaluronidase when vascular complications develop. However, multiple factors must be considered before injecting hyaluronidase. This report proposed five important considerations for hyaluronidase injection. Publication History Article published online: 30 July 2022 © 2022. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA