2022•Cancer ResearchRequires access

The Central Role of mTORC1 in Amino Acid Sensing

Shusheng Yue, Guanya Li, Shanping He, Tingting Li

Abstract

The mTOR is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have emphasized the importance of lysosomes as a hub for nutrient sensing, especially amino acid sensing by mTORC1. This review highlights recent advances in understanding the amino acid-mTORC1 signaling axis and the role of mTORC1 in cancer.

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Key concepts: mTORC1, Nutrient sensing, Regulator, Amino acid, PI3K/AKT/mTOR pathway, Master regulator, Cell biology, Biology