2022•The Journal of Organic ChemistryRequires access

Enantioselective Friedel–Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Brønsted Acid Catalysis

Wenxuan Zhang, Jiaying Sun, Zhendong Lian, Ran Song, Daoshan Yang, Jian Lv

Abstract

Herein, we report chiral strong Brønsted acid-catalyzed enantioselective Friedel-Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee.

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Key concepts: Friedel–Crafts reaction, Chemistry, Enantioselective synthesis, Brønsted–Lowry acid–base theory, Catalysis, Yield (engineering), Organic chemistry, Acid catalysis