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2022•Molecular PharmacologyOpen access

Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells

Apurva A. Oak, Tifany Chu, Pattareeya Yottasan, Parth D. Chhetri, Jie Zhu, J. Du Bois, Onur Çil

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Key concepts: Lubiprostone, Chloride channel, Cystic fibrosis transmembrane conductance regulator, Forskolin, Chemistry, Secretion, Activator (genetics), Apical membrane

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Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells — Research Paper | ScholarLens