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2022•Journal of Biochemical and Molecular ToxicologyRequires access

Design and synthesis of benzimidazole derivatives as antimycobacterial agents

Gagandeep Sindhu, Rohit Kholiya, Saqib Kidwai, Padam Singh, Ramandeep Singh, Diwan Singh Rawat

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Abstract

Abstract A series of 2,5‐disubstituted benzimidazole derivatives was synthesized with the aim to identify compounds with potent anti‐TB activity. All the compounds were screened in vitro against cultured Mycobacterium tuberculosis H37Rv strain and found to be exhibiting MIC99 values in the range of 0.195–100 µM. Out of 43 synthesized compounds, two compounds 11h and 13e showed better anti‐TB activity than the reference drug isoniazid.

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What this paper is about

Abstract A series of 2,5‐disubstituted benzimidazole derivatives was synthesized with the aim to identify compounds with potent anti‐TB activity. All the compounds were screened in vitro against cultured Mycobacterium tuberculosis H37Rv strain and found to be exhibiting MIC99 values in the range of 0.195–100 µM. Out of 43 synthesized compounds, two compounds 11h and 13e showed better anti‐TB activity than the reference drug isoniazid.

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Available abstract

Abstract A series of 2,5‐disubstituted benzimidazole derivatives was synthesized with the aim to identify compounds with potent anti‐TB activity. All the compounds were screened in vitro against cultured Mycobacterium tuberculosis H37Rv strain and found to be exhibiting MIC99 values in the range of 0.195–100 µM. Out of 43 synthesized compounds, two compounds 11h and 13e showed better anti‐TB activity than the reference drug isoniazid.

Key concepts: Antimycobacterial, Benzimidazole, Isoniazid, Mycobacterium tuberculosis, In vitro, Chemistry, Combinatorial chemistry, Stereochemistry

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