Study on Effect of Filgrastim in Severe Leukopenia Condition in Dogs

Filgrastim is a recombinant Methionyl Human Granulocyte- Stimulating Factor (r-metHuGCSF) analog used to stimulate the proliferation and differentiation of granulocytes in humans. Young pups and kittens suffer from severe leukopenia and neutropenia condition (etiology may be viral or bacterial or parasitic). Neutrophils being first line of defense in immunity system and decreased count may lead to increased mortality. In the present investigation 3 dogs with severe leukopenia and neutropenia condition when treated dogs with Filgrastim @ 10 μg/ kg b.wt. s.c daily for three days along with other supportive treatment, was found to be effective in correcting the hematological parameters within 48 hours of last dose of treatment and all those showed fast recovery also.