IN VIVO STUDY OF PHARMACOLOGICAL ACTIVITIES OF CALOTROPIS PROCERA: AN OVERVIEW

Calotropis is one of the widely distributed plants along the world’s geographical area. Many studies have been conducted to prove the pharmacological activities of Calotropis procera (Arka). It is classified as Upavisha in Ayurveda by Bhavprakasha and Rasatarangini. In its therapeutic application mentioned in various classical texts, Calotropis procera is treating almost 58 diseases having its 547 formulations which are indicated. It contains many phytochemical constituents like Cardenolides, Benzoyllineolone, Calactin, Calotropagenin etc. These phytoconstituents have proven anti-inflammatory, anticonvulsant, hepatoprotective, antitumor, and cytotoxic properties. In this review, a thorough literature search has been done through various textbooks, research magazines and internet search engines like PubMed, Google Scholar etc. Different In Vivo studies carried out on Calotropis procera to assess its pharmacological activities are considered. Meticulous analysis of these studies has been done with special reference to plant parts and their extraction method, animal models, assessment criterion and study outcomes. This provides additional information to carry out further research on Calotropis procera. The present review may be useful to researchers as a ready reckoner for their studies.