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1988•FEMS Microbiology LettersOpen access

A mouse model of Haemophilus ducreyi infection (chancroid)

M Tuffrey

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Abstract

Six- to 8-week-old CBA mice were inoculated intradermally and/or subcutaneously on each flank with one of 3 strains of Haemophilus ducreyi, 2 of these being recent isolates and the other a reference strain. Pustular nodules developed at all sites the day after 107 organisms had been given. Severe ulceration similar to chancroid occurred in about half of the lesions which took at least 13 days to heal. All three strains of H. ducreyi were isolated from the mice during the first week. The model is invaluable in helping to understand the pathogenicity of H. ducreyi as well as the immunopathogenesis and other aspects of chancroid.

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Six- to 8-week-old CBA mice were inoculated intradermally and/or subcutaneously on each flank with one of 3 strains of Haemophilus ducreyi, 2 of these being recent isolates and the other a reference strain. Pustular nodules developed at all sites the day after 107 organisms had been given. Severe ulceration similar to chancroid occurred in about half of the lesions which took at least 13 days to heal. All three strains of H. ducreyi were isolated from the mice during the first week. The model is invaluable in helping to understand the pathogenicity of H. ducreyi as well as the immunopathogenesis and other aspects of chancroid.

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Available abstract

Six- to 8-week-old CBA mice were inoculated intradermally and/or subcutaneously on each flank with one of 3 strains of Haemophilus ducreyi, 2 of these being recent isolates and the other a reference strain. Pustular nodules developed at all sites the day after 107 organisms had been given. Severe ulceration similar to chancroid occurred in about half of the lesions which took at least 13 days to heal. All three strains of H. ducreyi were isolated from the mice during the first week. The model is invaluable in helping to understand the pathogenicity of H. ducreyi as well as the immunopathogenesis and other aspects of chancroid.

Key concepts: Haemophilus ducreyi, Chancroid, Pasteurellaceae, Microbiology, Virology, Inoculation, Pathogenicity, Strain (injury)

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