Role of laboratory tests in diagnosis of multiple myeloma and other plasmocytes dyscrasia patients

Plasma cell dyscrasia is a group of diseases characterized by uncontrolled proliferation of single clone of plasma cells producing monoclonal protein – immunoglobulin and/or its subunits (light and heavy chains). Monoclonal protein most often can be detected as an extra band on serum protein pattern, nevertheless if it is lacking pathological condition cannot be excluded. Multiple myeloma is the most common gammapathy and the diagnostic criteria are well précised and updated. In case of the others like AL amyloidosis many problems with interpretation of laboratory results exist. For solving them besides of well established laboratory tests like serum protein electrophoresis the others like serum free light chains are being introduced. The own results illustrating laboratory picture of discrasia are presented.