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2019•University of Thi-Qar Journal of ScienceOpen access

Synthesis and Biological Activity study of some New Isonicotinic Acid Hydrazide (isoniazid) Derivatives

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Abstract

The work was included the synthesis of some new allyl , vinyl , tosyl and methyl derivatives for isonicotinic acid hydrazide( isoniazid ).The products were characterized by elemental analysis besides the IR and 1 H-NMR spectroscopic identifications .The work was also included the study of the biological activity of the products , starting material (isoniazid) and some antibiotics ,.This study shows that the biological activity of products is more than that of the isoniazid and the antibiotics.

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The work was included the synthesis of some new allyl , vinyl , tosyl and methyl derivatives for isonicotinic acid hydrazide( isoniazid ).The products were characterized by elemental analysis besides the IR and 1 H-NMR spectroscopic identifications .The work was also included the study of the biological activity of the products , starting material (isoniazid) and some antibiotics ,.This study shows that the biological activity of products is more than that of the isoniazid and the antibiotics.

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Available abstract

The work was included the synthesis of some new allyl , vinyl , tosyl and methyl derivatives for isonicotinic acid hydrazide( isoniazid ).The products were characterized by elemental analysis besides the IR and 1 H-NMR spectroscopic identifications .The work was also included the study of the biological activity of the products , starting material (isoniazid) and some antibiotics ,.This study shows that the biological activity of products is more than that of the isoniazid and the antibiotics.

Key concepts: Isonicotinic acid, Hydrazide, Isoniazid, Chemistry, Niacin, Pharmacology, Combinatorial chemistry, Biochemistry

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