Strategies and Methods in Monitoring and Targeting Protein–Protein Interactions

Abstract Since protein–protein interactions play a role in nearly all events that take place in a cell, information on the function of an unknown protein can be obtained by investigating its interaction with other proteins whose functions are already known. The manipulation of protein–protein interactions that contribute to disease is a potential therapeutic strategy. This article focuses on protein–protein interactions and screening strategies to characterize new inhibitory molecules that act by disrupting biologically relevant protein–protein interactions.