2004•Methods and principles in medicinal chemistryRequires access

Chemical Kinomics

Bert Klebl, Henrik Daub, Gÿorgý Kéri

Abstract

This chapter contains sections titled: Introduction Chemical Biology: The Hope Chemical Kinomics: A Target Gene Family Approach in Chemical Biology Protein Kinase Inhibitor History Chemical Kinomics: An Amenable Approach Examples of Traditional Chemical Genomics Using Kinase Inhibitors Forward Chemical Genomics Using a Kinase-biased Compound Library Chemical Validation Orthogonal Chemical Genetics ASKAs: Analog-sensitive Kinase Alleles Cohen's Inhibitor-insensitive p38 Mutants Active Inhibitor-insensitive Kinase Mutants (Orthogonal Protein Kinases) Chemical Proteomics for Kinases: KinaTorTM Conclusions

About this research paper

What this paper is about

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Chemical genetics, Chemical biology, Kinase, Chemical library, Mutant, Genomics, Computational biology, Biochemistry