2016•Survey of AnesthesiologyRequires access
2,3-Diphosphoglycerate Concentrations in Autologous Salvaged Versus Stored Red Blood Cells in Surgical Patients After Transfusion
Andrew V. Scott, Enika Nagababu, Daniel J. Johnson, Khaled M. Kebaish, Joshua A. Lipsitz, Ian M. Dwyer, Gabriel S. Zuckerberg, Viachaslau Barodka, Dan E. Berkowitz, Steven M. Frank
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Abstract
(Abstracted from Anesth Analg, 122:616–623, 2016) Red blood cells (RBCs) undergo morphological and biochemical changes in structure during storage and are at risk of storage lesions and loss of 2,3-diphosoglycerate (2,3-DPG). In fact, 2,3-DPG is nearly depleted after 21 days of storage, and although the issue is controversial, it is thought that reduced 2,3-DPG may adversely affect oxygen delivery, seen through a shift of the oxyhemoglobin dissociation curve to the left and subsequent decrease in P50 (partial pressure of oxygen at which 50% of hemoglobin is saturated with O2).