Cutaneous Post‐transplant Lymphoproliferative Disorders

Lymphoproliferative disorders are one of the most common malignancies in recipients of solid organ and bone marrow transplantation, developing in approximately 2% of patients. This chapter talks about the clinical features, histopathology, immunophenotype, molecular genetics, treatment, and prognosis of cutaneous post-transplant lymphoproliferative disorders. Post-transplant lymphoproliferative disorders are classified according to four major categories: (i) early lesions (reactive plasmacytic hyperplasia, infectious mononucleosis-like lesions); (ii) polymorphic post-transplant lymphoproliferative disorder; (iii) monomorphic post-transplant lymphoproliferative disorder, with clinicopathologic features corresponding to “conventional” entities of B- and NK/T-cell lymphomas; and (iv) classical Hodgkin lymphoma-type post-transplant lymphoproliferative disorder. The chapter also presents a short résumé of cutaneous post-transplant lymphoproliferative disorders.