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2007•Alcohol and AlcoholismOpen access

Oral Communication 12, Tuesday Sept. 25th 5.00 pm-6.00 pm; Room: Lecture Hall 3: Pharmacological approaches to addictive behaviour--Part 2

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Abstract

Aims. Gamma-hydroxybutyric acid (GHB) is currently used in several European Countries, including Italy, for the treatment of alcohol dependence. It reduces alcohol drinking, promotes abstinence from alcohol, suppresses craving for alcohol, and ameliorates alcohol withdrawal syndrome. Consistently, administration of GHB has been found to suppress alcohol withdrawal signs and alcohol intake in rat models of alcohol dependence. The present study was designed to investigate whether GHB administration was capable of affecting alcohol's motivational properties (the possible animal correlate of human craving for alcohol) in selectively bred Sardinian alcohol-preferring (sP) rats.

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Aims. Gamma-hydroxybutyric acid (GHB) is currently used in several European Countries, including Italy, for the treatment of alcohol dependence. It reduces alcohol drinking, promotes abstinence from alcohol, suppresses craving for alcohol, and ameliorates alcohol withdrawal syndrome. Consistently, administration of GHB has been found to suppress alcohol withdrawal signs and alcohol intake in rat models of alcohol dependence. The present study was designed to investigate whether GHB administration was capable of affecting alcohol's motivational properties (the possible animal correlate of human craving for alcohol) in selectively bred Sardinian alcohol-preferring (sP) rats.

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Available abstract

Aims. Gamma-hydroxybutyric acid (GHB) is currently used in several European Countries, including Italy, for the treatment of alcohol dependence. It reduces alcohol drinking, promotes abstinence from alcohol, suppresses craving for alcohol, and ameliorates alcohol withdrawal syndrome. Consistently, administration of GHB has been found to suppress alcohol withdrawal signs and alcohol intake in rat models of alcohol dependence. The present study was designed to investigate whether GHB administration was capable of affecting alcohol's motivational properties (the possible animal correlate of human craving for alcohol) in selectively bred Sardinian alcohol-preferring (sP) rats.

Key concepts: Alcohol, Craving, Abstinence, Alcohol addiction, Alcohol withdrawal syndrome, Alcohol dependence, Ethanol, Addiction

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Oral Communication 12, Tuesday Sept. 25th 5.00 pm-6.00 pm; Room: Lecture Hall 3: Pharmacological approaches to addictive behaviour--Part 2 — Research Paper | ScholarLens