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Effect of human recombinant granulocyte colony-stimulating factor on hematopoietic injury in mice induced by 5-fluorouracil

M Shimamura, Yukio Kobayashi, A Yuo, A Urabe, T Okabe, Y Komatsu, S Itoh, Fumimaro Takaku

Abstract

Intravenous (IV) administration of 5-fluorouracil (5-FU) caused severe hematopoietic injury in mice. Daily administration of purified human recombinant granulocyte colony-stimulating factor (rG-CSF) accelerated recovery from neutropenia in these injured mice. Granulocyte-macrophage progenitors (CFU-GM) in spleen were markedly increased by rG-CSF, while rG-CSF was less effective on the regeneration of CFU-GM in femoral marrow. The accelerated recovery from neutropenia in the mice might be mainly due to the stimulation of granulopoiesis in spleen by rG-CSF.

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Available abstract

Key concepts: Granulopoiesis, Neutropenia, Granulocyte, Haematopoiesis, Granulocyte colony-stimulating factor, Colony-stimulating factor, Spleen, Granulocyte macrophage colony-stimulating factor