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Transmission/Disequilibrium Test

Françoise Seillier‐Moiseiwitsch, Tianhua Niu

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Abstract

Abstract The transmission/disequilibrium test (TDT) can be utilized as a test of linkage between a marker and a disease locus or as a test of association between these loci. It relies on the marker information from triads consisting of parents and their affected child. Its properties depend on the purpose it is used for. Its validity for stratified populations makes it particularly attractive. Also, it is often more powerful than allele‐sharing methods for complex diseases.

About this research paper

What this paper is about

Abstract The transmission/disequilibrium test (TDT) can be utilized as a test of linkage between a marker and a disease locus or as a test of association between these loci. It relies on the marker information from triads consisting of parents and their affected child. Its properties depend on the purpose it is used for. Its validity for stratified populations makes it particularly attractive. Also, it is often more powerful than allele‐sharing methods for complex diseases.

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Available abstract

Abstract The transmission/disequilibrium test (TDT) can be utilized as a test of linkage between a marker and a disease locus or as a test of association between these loci. It relies on the marker information from triads consisting of parents and their affected child. Its properties depend on the purpose it is used for. Its validity for stratified populations makes it particularly attractive. Also, it is often more powerful than allele‐sharing methods for complex diseases.

Key concepts: Transmission disequilibrium test, Linkage disequilibrium, Disequilibrium, Locus (genetics), Test (biology), Allele, Genetics, Biology

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