2003Encyclopedia of Life SciencesRequires access

Nonsense Mutations and Suppression

Muriel B. Herrington

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Abstract

Abstract A nonsense mutation occurs when a codon that codes for an amino acid is changed to a chain‐termination codon. Informational suppression of a nonsense mutation occurs when changes in the translation apparatus enable the cell to insert an amino acid in response to the nonsense codon, resulting in a wild‐type or near wild‐type phenotype.

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What this paper is about

Abstract A nonsense mutation occurs when a codon that codes for an amino acid is changed to a chain‐termination codon. Informational suppression of a nonsense mutation occurs when changes in the translation apparatus enable the cell to insert an amino acid in response to the nonsense codon, resulting in a wild‐type or near wild‐type phenotype.

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Available abstract

Abstract A nonsense mutation occurs when a codon that codes for an amino acid is changed to a chain‐termination codon. Informational suppression of a nonsense mutation occurs when changes in the translation apparatus enable the cell to insert an amino acid in response to the nonsense codon, resulting in a wild‐type or near wild‐type phenotype.

Key concepts: Nonsense mutation, Nonsense, Genetics, Stop codon, Translation (biology), Mutation, Amino acid, Biology

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