2010•Comprehensive Organic Name Reactions and ReagentsRequires access

Craig 2‐Bromo‐Pyridine Synthesis

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Abstract

Abstract The method for preparing 2‐bromo‐pyridine in high yield from 2‐amino‐pyridine is known as Craig 2‐bromo‐pyridine synthesis. The concentrated aqueous solution of sodium nitrite and 2‐amino‐pyridine have been added to a concentrated hydrobromic acid saturated with bromine to obtain optimum yield of 2‐bromo‐pyridine. This reaction has application for the preparation of 2‐bromo‐pyridine and 2‐bromopyrimidine.

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Available abstract

Key concepts: Pyridine, Yield (engineering), Chemistry, Hydrobromic acid, Bromine, Sodium nitrite, Aqueous solution, Organic chemistry