Preservation of Coagulation Factors V and VIII during Collection and Subsequent Storage of Bank Blood in ACD-A and CPD Solutions

Predonation levels and levels in ACD-A and CPD blood units stored for up to 21 days under standard blood bank conditions were assayed for factors V and VIII. Factor V activity decreased slowly and almost alike in both groups, reaching 40% in ACD-A and 31 % in CPD bottles after 3 weeks of storage. Factor VIII activity fell from predonation level 102 to 73 % in ACD-A and 107 to 97 % in CPD units within 2 h of blood collection. Subsequent loss was rapid in both groups, reaching 23 and 33 % after 1 week, 14 and 12% after 3 weeks, respectively. The findings indicate that factor VIII is better preserved in fresh CPD than in fresh ACD-A bank blood.