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1972•Acta Medica ScandinavicaRequires access

COMPARISON BETWEEN ALPRENOLOL AND PROPRANOLOL AS ANTIHYPERTENSIVE AGENTS

Calle Bengtsson

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Abstract

AbstractA double‐blind cross‐over study comparing alprenolol and propranolol in equipotent β‐blocking doses has been performed in 26 subjects with mild hypertension. Alprenolol and propranolol had an almost identical BP‐reducing effect. Propranolol reduced the heart rate significantly more than alprenolol, indicating different mechanisms of action for the antihypertensive effect. Subjective symptoms which could be interpreted as side‐effects were few and transient with both drugs. Both alprenolol and propranolol seem well suited for the treatment of mild hypertension.

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What this paper is about

AbstractA double‐blind cross‐over study comparing alprenolol and propranolol in equipotent β‐blocking doses has been performed in 26 subjects with mild hypertension. Alprenolol and propranolol had an almost identical BP‐reducing effect. Propranolol reduced the heart rate significantly more than alprenolol, indicating different mechanisms of action for the antihypertensive effect. Subjective symptoms which could be interpreted as side‐effects were few and transient with both drugs. Both alprenolol and propranolol seem well suited for the treatment of mild hypertension.

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Available abstract

AbstractA double‐blind cross‐over study comparing alprenolol and propranolol in equipotent β‐blocking doses has been performed in 26 subjects with mild hypertension. Alprenolol and propranolol had an almost identical BP‐reducing effect. Propranolol reduced the heart rate significantly more than alprenolol, indicating different mechanisms of action for the antihypertensive effect. Subjective symptoms which could be interpreted as side‐effects were few and transient with both drugs. Both alprenolol and propranolol seem well suited for the treatment of mild hypertension.

Key concepts: Alprenolol, Propranolol, Medicine, Heart rate, Pharmacology, Cardiology, Blood pressure, Internal medicine

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