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2009•Biochemical Society TransactionsRequires access

RDL receptors

Ian McGonigle, Sarah C. R. Lummis

Open publisher page 18 citations

Abstract

RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (gamma-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABA(A) receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT(3) receptors. RDL receptors are widely expressed throughout the insect CNS (central nervous system) and are important in inhibitory neurotransmission. They are therefore a major insecticidal target site.

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What this paper is about

RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (gamma-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABA(A) receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT(3) receptors. RDL receptors are widely expressed throughout the insect CNS (central nervous system) and are important in inhibitory neurotransmission. They are therefore a major insecticidal target site.

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OpenAlex reports 18 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (gamma-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABA(A) receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT(3) receptors. RDL receptors are widely expressed throughout the insect CNS (central nervous system) and are important in inhibitory neurotransmission. They are therefore a major insecticidal target site.

Key concepts: Ionotropic effect, Class C GPCR, Rhodopsin-like receptors, Receptor, Ion channel linked receptors, Glycine receptor, Nicotinic agonist, GABAA receptor

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