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Separation of N-TFA-Glycyl and N-TFA- l -Prolyl Dipeptide Methyl Esters by Gas-chromatography

Ichiro Tomida, Mitoshi Kon’no, Hitoshi Tokumori, Takeshi Yasui, Hiroshi Kayahara, Ryozo Iriye

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Abstract

We have prepared a series of N-TFA-glycyl and N-TFA-l-prolyl dipeptide methyl ester from the corresponding dipeptide methyl esters by treating them with (TFA-Gly)2O and TFA-l-Pro-Cl, respectively. Separation of these tripeptide derivatives by G.L.C. was studied and a relationship between the amino acid compositions of the tripeptides and their qi-values (relative retention values) was observed, analogous to the case of the dipeptides previously reported.

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What this paper is about

We have prepared a series of N-TFA-glycyl and N-TFA-l-prolyl dipeptide methyl ester from the corresponding dipeptide methyl esters by treating them with (TFA-Gly)2O and TFA-l-Pro-Cl, respectively. Separation of these tripeptide derivatives by G.L.C. was studied and a relationship between the amino acid compositions of the tripeptides and their qi-values (relative retention values) was observed, analogous to the case of the dipeptides previously reported.

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Available abstract

We have prepared a series of N-TFA-glycyl and N-TFA-l-prolyl dipeptide methyl ester from the corresponding dipeptide methyl esters by treating them with (TFA-Gly)2O and TFA-l-Pro-Cl, respectively. Separation of these tripeptide derivatives by G.L.C. was studied and a relationship between the amino acid compositions of the tripeptides and their qi-values (relative retention values) was observed, analogous to the case of the dipeptides previously reported.

Key concepts: Dipeptide, Tripeptide, Chemistry, Amino acid, Peptide, Oligopeptide, Stereochemistry, Chromatography

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