Post‐Metalation Structural Insights into the Use of Alkali‐Metal‐Mediated Zincation for Directed ortho‐Metalation of a Tertiary Aromatic Amide
W. Clegg, Sophie H. Dale, Ross W. Harrington, Eva Hevia, G.W. Honeyman, Robert E. Mulvey
Abstract
W. Clegg, Sophie H. Dale, Ross W. Harrington, Eva Hevia, G.W. Honeyman, Robert E. Mulvey
Abstract
Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.
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Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.
Key concepts: Metalation, Amide, Alkali metal, Electrophile, Chemistry, Electrophilic substitution, Combinatorial chemistry, Organic chemistry