2006Angewandte Chemie International EditionRequires access

Post‐Metalation Structural Insights into the Use of Alkali‐Metal‐Mediated Zincation for Directed ortho‐Metalation of a Tertiary Aromatic Amide

W. Clegg, Sophie H. Dale, Ross W. Harrington, Eva Hevia, G.W. Honeyman, Robert E. Mulvey

Open publisher page 95 citations

Abstract

Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.

About this research paper

What this paper is about

Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.

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OpenAlex reports 95 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Catch me if you can: Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.

Key concepts: Metalation, Amide, Alkali metal, Electrophile, Chemistry, Electrophilic substitution, Combinatorial chemistry, Organic chemistry

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Post‐Metalation Structural Insights into the Use of Alkali‐Metal‐Mediated Zincation for Directed ortho‐Metalation of a Tertiary Aromatic Amide — Research Paper | ScholarLens