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2018•Unpublished venueOpen access

Determination of Effective Synaptic Conductances Using Somatic Voltage Clamp v1

Songting Li, Nan Liu, Xiaohui Zhang, Douglas Zhou, David Cai

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Abstract

By using dynamic clamp to generate synaptic inputs, we demonstrate the deficiency of the traditional slope-and-intercept method for the determination of effective synaptic conductances using somatic voltage clamp, and and we test the effectiveness of the intercept method for the measurement of effective conductance.

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What this paper is about

By using dynamic clamp to generate synaptic inputs, we demonstrate the deficiency of the traditional slope-and-intercept method for the determination of effective synaptic conductances using somatic voltage clamp, and and we test the effectiveness of the intercept method for the measurement of effective conductance.

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Available abstract

By using dynamic clamp to generate synaptic inputs, we demonstrate the deficiency of the traditional slope-and-intercept method for the determination of effective synaptic conductances using somatic voltage clamp, and and we test the effectiveness of the intercept method for the measurement of effective conductance.

Key concepts: Clamp, Voltage clamp, Conductance, Patch clamp, Current clamp, Voltage, Somatic cell, Neuroscience

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