[Bizarre leiomyoma of the uterus--a clinicopathological analysis of 21 cases].

Twenty-one patients with bizarre leiomyoma of uterus treated in the Obstetrics and Gynecology Hospital, Zhejiang Medical College from 1968 to 1988 are reported. These accounted for 1% of patients with uterine myogenic tumors in the same period. All were multipara. Their age ranged from 25 to 59 years with an average of 41.3 years. Of these 21 cases, 7 had taken oral contraceptives, 3 had had IUD, 8 had undergone tubosterilization and 3 had concurrent pregnancy. Twelve cases were diagnosed as bizarre leiomyoma of uterus by pathology and 9 as leiomyoma with sarcoma-like changes in limited areas or leiomyosarcoma. Among these 21 cases, 9 had limited focal bizarre leiomyoma and 12 pseudosarcomatoid tumor. The bizarre leiomyoma of uterus is of benign nature. Its treatment is similar to that of the common leiomyoma. Its occurrence might be related to the primary leiomyoma of uterus under constant influence of high level sex hormone or being of bizarre cell type at the very beginning. The differentiation between the bizarre leiomyoma of uterus and leiomyosarcoma is discussed.