Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats

Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demeth-ylase and aniline hydroxylase.