2015•Cell ReportsOpen access
NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells
Alessandro Fantin, Αναστασία Λαμπροπούλου, Gaia Gestri, Claudio Raimondi, Valentina Senatore, Ian Zachary, Christiana Ruhrberg
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Abstract
(Cell Reports 11, 1577–1590; June 16, 2015) In the originally published version of this paper, Figure 7D contained an image inadvertently duplicated from a previously published paper. The figure has been updated with the relevant correct panel and now appears corrected with the paper online. The authors apologize for this error. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip CellsFantin et al.Cell ReportsJune 3, 2015In BriefDuring angiogenesis, new blood vessel sprouts are led by filopodia-studded tip cells to sense environmental signals and enable directional migration. NRP1 is a tip cell protein that senses angiogenic cues. Fantin et al. now show that NRP1 promotes tip cell function by enabling CDC42 activation for filopodia formation and actin remodeling. Full-Text PDF Open Access
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