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Calorimetry

Kenneth P. Murphy

Abstract

Abstract In isothermal titration calorimetry, the heat produced or absorbed when a ligand binds to a biological macromolecule is measured and is used to characterize the energetics of the interaction. All of the thermodynamic quantities that characterize the binding reaction can be determined, and additional information on changes in protonation, and thus pH dependence, can also be studied.

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Available abstract

Key concepts: Isothermal titration calorimetry, Calorimetry, Chemistry, Protonation, Energetics, Thermodynamics, Titration, Macromolecule