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1972•The Japanese Journal of PharmacologyOpen access

Effect of Noradrenaline on Non-Adrenergic Inhibitory Response of Guinea-Pig Taenia Coli

Mitsuo Sakato, Yasuo Shimo, T. Bando

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Abstract

It has been shown pharmacologically that the smooth muscle of the guinea-pig taenia coli is supplied with two types of inhibitory nerves; adrenergic nerves and non-adrenergic nerves. Recently Burnstock et al. (1) have suggested that ATP or related nucleotide is a transmitter substance of non-adrenergic inhibitory nerves. It would be of great interest to determine whether or not any differences exist between an inhibitory response to ATP and stimulation of non-adrenergic nerves under various conditions.

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What this paper is about

It has been shown pharmacologically that the smooth muscle of the guinea-pig taenia coli is supplied with two types of inhibitory nerves; adrenergic nerves and non-adrenergic nerves. Recently Burnstock et al. (1) have suggested that ATP or related nucleotide is a transmitter substance of non-adrenergic inhibitory nerves. It would be of great interest to determine whether or not any differences exist between an inhibitory response to ATP and stimulation of non-adrenergic nerves under various conditions.

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Available abstract

It has been shown pharmacologically that the smooth muscle of the guinea-pig taenia coli is supplied with two types of inhibitory nerves; adrenergic nerves and non-adrenergic nerves. Recently Burnstock et al. (1) have suggested that ATP or related nucleotide is a transmitter substance of non-adrenergic inhibitory nerves. It would be of great interest to determine whether or not any differences exist between an inhibitory response to ATP and stimulation of non-adrenergic nerves under various conditions.

Key concepts: Taenia coli, Adrenergic, Inhibitory postsynaptic potential, Taenia, Stimulation, Guinea pig, Endocrinology, Internal medicine

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