1979•Drug and Therapeutics BulletinRequires access

Theophylline in asthma

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Abstract

Theophylline and aminophylline (theophylline made soluble by complexing with ethylenediamine) resemble β-adrenergic agonists such as salbutamol and terbutaline in their bronchodilator effect. The latter drugs act by promoting the synthesis of cyclic AMP in target cells; the former delay the inactivation of cyclic AMP by competitive inhibition of phosphodiesterase.

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Key concepts: Aminophylline, Theophylline, Bronchodilator, Terbutaline, Salbutamol, Bronchodilator Agents, Phosphodiesterase, Chemistry