VP26.01: Small head circumference at fetal ultrasound: when should we counsel for microcephaly?

To assess outcome of children diagnosed prenatally with microcephaly (head circumference smaller than 2 standard deviations below the mean) at Fetal Medicine of Policlinico Sant'Orsola, Bologna. A retrospective cohort study of singleton pregnancies, suspected for microcephaly and examined by multiplanar fetal neurosonogram, according to ISUOG guidelines, between January 2008 and March 2020. Over 12 years, 48 singleton microcephalic fetuses, were found in our archives. 12 underwent voluntary termination because this finding (isolated or associated with other abnormalities). Diagnosis was performed during late second trimester and confirmed as isolated for 22 fetuses (46%). In four cases a concomitant heart disease was found. The mean gestational age at delivery was 36.5 weeks. A head circumference below the 5th centile was confirmed for 8 newborns (36%). Complete results are collected in table 1. All the confirmed microcephalic newborns had normal chromosomes, no other structural abnormalities and no evidence of intrauterine infection or maternal alcohol/drug abuse. The pediatric followup was, at time of this study, available only for 7 newborns and documented a normal neurologic development per age. The postnatal ultrasound examination do not prove the presence of other abnormalities. All these findings should help in the counselling of couples referred for a prenatal isolated microcephaly. Supporting information can be found in the online version of this abstract Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.