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2020•Unpublished venueOpen access

Improved force fields for the simulations of structural and thermal dynamics of peptide nucleic acid (PNA) complexes with natural nucleic acids

Maciej Jasiński, Joanna Miszkiewicz, Joanna Trylska, Michael Feig

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Abstract

Peptide nucleic acid (PNA) is a synthetic DNA analog with the phosphate backbone replaced by the N-(2-aminoethyl)-glycine units. Even though the PNA backbone resembles the neutral peptide backbone, the PNA is structurally similar to DNA or RNA. Thus, PNA oligomers, obeying the Watson-Crick base pairing rules, form stable duplexes and triplexes with DNA and RNA. Since PNA is a

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What this paper is about

Peptide nucleic acid (PNA) is a synthetic DNA analog with the phosphate backbone replaced by the N-(2-aminoethyl)-glycine units. Even though the PNA backbone resembles the neutral peptide backbone, the PNA is structurally similar to DNA or RNA. Thus, PNA oligomers, obeying the Watson-Crick base pairing rules, form stable duplexes and triplexes with DNA and RNA. Since PNA is a

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Available abstract

Peptide nucleic acid (PNA) is a synthetic DNA analog with the phosphate backbone replaced by the N-(2-aminoethyl)-glycine units. Even though the PNA backbone resembles the neutral peptide backbone, the PNA is structurally similar to DNA or RNA. Thus, PNA oligomers, obeying the Watson-Crick base pairing rules, form stable duplexes and triplexes with DNA and RNA. Since PNA is a

Key concepts: Nucleic acid, Peptide nucleic acid, Molecular dynamics, Nucleic acid structure, Chemistry, Dynamics (music), Peptide, Biophysics

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