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1967•Drug and Therapeutics BulletinRequires access

Prothionamide and capreomycin for tuberculosis

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Abstract

Tuberculosis is usually arrested by prolonged uninterrupted administration of a combination of isoniazid, sodium aminosalicylate (PAS) and streptomycin. Should this fail because of the emergence of drug-resistant organisms or intractable drug hypersensitivity, a combination including or entirely made up of ‘second-line’ drugs such as ethionamide, cycloserine, pyrazinamide, viomycin or kanamycin may be used. Two new ‘second-line’ drugs are prothionamide (Trevintix - M & B) and capreomycin (Dista).

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What this paper is about

Tuberculosis is usually arrested by prolonged uninterrupted administration of a combination of isoniazid, sodium aminosalicylate (PAS) and streptomycin. Should this fail because of the emergence of drug-resistant organisms or intractable drug hypersensitivity, a combination including or entirely made up of ‘second-line’ drugs such as ethionamide, cycloserine, pyrazinamide, viomycin or kanamycin may be used. Two new ‘second-line’ drugs are prothionamide (Trevintix - M & B) and capreomycin (Dista).

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Available abstract

Tuberculosis is usually arrested by prolonged uninterrupted administration of a combination of isoniazid, sodium aminosalicylate (PAS) and streptomycin. Should this fail because of the emergence of drug-resistant organisms or intractable drug hypersensitivity, a combination including or entirely made up of ‘second-line’ drugs such as ethionamide, cycloserine, pyrazinamide, viomycin or kanamycin may be used. Two new ‘second-line’ drugs are prothionamide (Trevintix - M & B) and capreomycin (Dista).

Key concepts: Capreomycin, Ethionamide, Cycloserine, Pyrazinamide, Streptomycin, Viomycin, Isoniazid, Tuberculosis

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