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ChemInform Abstract: Reaction of 4‐Bromo‐1,2‐dimethylbenzene with Various Nucleophiles via Aryne Reaction.

E. R. BIEHL, Aziz Razzuk, Misa V. Jovanovic, S. P. KHANAPURE

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Abstract

Abstract 4‐Bromo‐o‐xylene (I) reacts with nucleophiles such as the amines (II), the nitriles (VII), or the thiols (X) in the presence of bases to produce predominantly the 4‐substituted derivatives (III), (VIII), or (XI).

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What this paper is about

Abstract 4‐Bromo‐o‐xylene (I) reacts with nucleophiles such as the amines (II), the nitriles (VII), or the thiols (X) in the presence of bases to produce predominantly the 4‐substituted derivatives (III), (VIII), or (XI).

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Method / approach

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Main findings

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Available abstract

Abstract 4‐Bromo‐o‐xylene (I) reacts with nucleophiles such as the amines (II), the nitriles (VII), or the thiols (X) in the presence of bases to produce predominantly the 4‐substituted derivatives (III), (VIII), or (XI).

Key concepts: Chemistry, Aryne, Nucleophile, Medicinal chemistry, Reaction conditions, Organic chemistry, Catalysis

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ChemInform Abstract: Reaction of 4‐Bromo‐1,2‐dimethylbenzene with Various Nucleophiles via Aryne Reaction. — Research Paper | ScholarLens