2008•Angewandte ChemieRequires access

Chiral Phosphoric Acid Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles with Nitroalkenes: Cooperative Effect of 3 Å Molecular Sieves

Junji Itoh, Kohei Fuchibe, Takahiko Akiyama

Abstract

Pfiffige Katalysatoren: Die Alkylierung von Indolen mit Nitroalkenen in Gegenwart des Phosphorsäurederivats 1 und eines 3-Å-Molekularsiebs liefert die Friedel-Crafts-Addukte mit ausgezeichneten Enantioselektivitäten (siehe Schema).

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Key concepts: Enantioselective synthesis, Friedel–Crafts reaction, Phosphoric acid, Alkylation, Catalysis, Chemistry, Molecular sieve, Organic chemistry