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2014•Practica Oto-Rhino-LaryngologicaRequires access

A Case of Langerhans Cell Histiocytosis of the Temporal Bone

Hiroki Onishi, Mika Takahashi, Kōji Abe, Noriaki Takeda

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Abstract

We report herein on a 19-year-old female with Langerhans cell histiocytosis (LCH) of the temporal bone. She complained of right ear fullness and showed conductive hearing loss of the right ear. CT imaging showed a tumor in the temporal bone and multiple nodules in the lung, and LCH was diagnosed by biopsy of the temporal bone tumor. After a series of remission-induction therapy of B1, but not A and maintenance therapy of B2 and C on the basis of the JLSG-02 protocol of the Japan LCH Study Group, LCH lesions in both organs disappeared and the defect of the temporal bone was replaced with new bone formation.

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What this paper is about

We report herein on a 19-year-old female with Langerhans cell histiocytosis (LCH) of the temporal bone. She complained of right ear fullness and showed conductive hearing loss of the right ear. CT imaging showed a tumor in the temporal bone and multiple nodules in the lung, and LCH was diagnosed by biopsy of the temporal bone tumor. After a series of remission-induction therapy of B1, but not A and maintenance therapy of B2 and C on the basis of the JLSG-02 protocol of the Japan LCH Study Group, LCH lesions in both organs disappeared and the defect of the temporal bone was replaced with new bone formation.

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Available abstract

We report herein on a 19-year-old female with Langerhans cell histiocytosis (LCH) of the temporal bone. She complained of right ear fullness and showed conductive hearing loss of the right ear. CT imaging showed a tumor in the temporal bone and multiple nodules in the lung, and LCH was diagnosed by biopsy of the temporal bone tumor. After a series of remission-induction therapy of B1, but not A and maintenance therapy of B2 and C on the basis of the JLSG-02 protocol of the Japan LCH Study Group, LCH lesions in both organs disappeared and the defect of the temporal bone was replaced with new bone formation.

Key concepts: Langerhans cell histiocytosis, Temporal bone, Histiocytosis, Medicine, Biopsy, Lung, Pathology, Conductive hearing loss

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