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Cell Cycle: Regulation by Cyclins

Ana A. Kitazono, Jonathan N. Fitz Gerald, Stephen J. Kron

Abstract

Abstract The cell cycle is defined as the periodic occurrence of events that are coordinately driven by the cyclin‐dependent kinases (CDKs). Cyclins are structurally related proteins whose levels fluctuate throughout the cell cycle. These CDK activators also impart distinct substrate specificity to CDKs for the temporal regulation of cell division.

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Key concepts: Cyclin-dependent kinase, Cyclin, Cell cycle, Cell biology, Polo-like kinase, Restriction point, Kinase, Cell division