2022•New Journal of ChemistryRequires access

Design, synthesis and antifungal mechanism of novel acetophenone derivatives containing 1,3,4-thiadiazole-2-thioethers

Li Dou, Huabin Shi, Xue Niu, Hong Zhang, Kankan Zhang, Zhibing Wu

Abstract

Key functional groups carbonyl and 1,3,4-thiadiazole-2-thiol can be obtained simultaneously in the present of sulfuric acid. Antifungal mechanism study revealed that the compound can change the permeability of the cell membrane, causing their death.

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Key concepts: Chemistry, Antifungal, Acetophenone, Sulfuric acid, Thiol, Membrane permeability, Combinatorial chemistry, Mechanism (biology)