2022•Journal of Biosciences and MedicinesOpen access

Effects of Different Doses of Doxorubicin on H9C2 Cells

Fan Xu, Xiao Li, Xiaolei Yu, Qingshan Li, Wenxin Li, Xiao Li Xu

Abstract

Objective: To study the effect of different doses of doxorubicin on H9C2 cells and to provide a reference for the clinical study of doxorubicin. Methods: Doxorubicin (1, 2, 4, 6, 10 ug/ml) was co-cultured with H9C2 cells for 6, 12 and 24 hours. The morphological changes of cells were observed, and the cell inhibition rates of different time and drug concentration were calculated. Results: Doxorubicin could inhibit the activity of cardiomyocytes in a dose-dependent manner from 1 to 10 ug/ml. Conclusion: A certain dose of doxorubicin has a toxic effect on cardiomyocytes and can cause cardiomyocyte necrosis and apoptosis.

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Key concepts: Doxorubicin, Apoptosis, Pharmacology, Necrosis, Cell culture, Chemistry, Cell, Medicine