2022•Proceedings for Annual Meeting of The Japanese Pharmacological SocietyOpen access

Analysis of the mechanism by which TSLP production is inhibited by PHD inhibitors

Makiko Yagisawa, Ryosuke Segawa, Naoyuki Tashiro, Noriyasu Hirasawa

Abstract

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays an important role in the regulation of skin immunity and is upregulated in the lesions of atopic dermatitis patients. Therefore, inhibitors of TSLP production are effective as therapeutic agents for atopic dermatitis. In our laboratory, we found that hypoxia condition and DMOG, a PHD inhibitor, suppressed the expression of TSLP in keratinocytes. In this study, we analyzed the mechanism by which PHD inhibitors suppress TSLP expression.

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Key concepts: Thymic stromal lymphopoietin, Atopic dermatitis, Mechanism (biology), Cytokine, Downregulation and upregulation, Immunology, Chemistry, Medicine